Diphtheria – Respiratory tract infection

Diphtheria is a respiratory tract infection. Agent of infection Corynebacterium diphtheriae Organism features Special features Virulence factors Diphtheria toxin (DT) Mechanism of action ↓ Fragment B binds to host cell receptors ↓ Helps in internalization of fragment A ↓ Fragment A causes ADP ribosylation of elongation factor 2 (EF-2) ↓ EF-2 inhibited ↓ inhibiton of translation (protein sysnthesis) … Read more